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Research studies performed show positive results to weight loss with the combination of the stimulants ephedrine and caffeine .

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We assessed the possibility of publication bias by evaluating a funnel plot of effect sizes for asymmetry, which results from the nonpublication of small, negative trials.

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It is not possible to estimate the degree to which caffeine contributes to these results, because there were too few trials of ephedrine alone or ephedra alone to support stratified analyses.

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